After a sleepless night, we were up early to head back to Dana-Farber where I would start the Crizotinib (PF 02341066) clinical trial at their Clinical Research Center. The day started with some preliminary tests; another doctors exam and a few EKGs. Then we met with the research nurse in charge of the study, who laid out the guidelines and discussed the potential side effects. I was familiar with most of the information, but it resonated louder when I was about to take the drug for the first time. The most difficult thing emphasized is that while on the drug, we absolutely cannot conceive a child because this is a new drug and the effects on a fetus are unknown. Shannon and I always wanted kids, but delayed for a time when our finances, careers, and education were in order; as of today, it is no longer an option. Our nieces and nephews will continue to have a lot of extra attention.
There are no guarantees with this drug, however, this is the best chance I have. The regiment: two 100 mg tablets and one 50 mg tablet, twice a day. The most common side effects: distorted vision (streaking), joint pain, mild nausea, and diarrhea. All small prices to pay for a longer life.
At 1030, with my fingers crossed, I took the first dose. I was anxious to get into this trial and start as early as possible to hopefully halt my growing tumors. However, when it was time to take the first dose I felt some apprehension. How am I going to respond to this drug? What if I have some unknown horrible side effect? This is a chemotherapy.
After taking the drug I did experience some slight abnormalities. You become paranoid and it is difficult to seperate normal fatigue, nausea, and stomach pains from the effects of the drug. At this point I have chalked it up to too little sleep and a McDonald’s lunch. In the movie “Supersize Me” they refer to this as the McGurgles.